Treatment: Potent systemic drugs (eg, methotrexate, cyclosporine, TNF-alpha inhibitor) or intense topical therapy, sometimes as inpatient therapy
6. Gower WR Jr. Mechanism of glucocorticoid action. J Fla Med Assoc. 1993;80:697–700.
Dates Loss of response and partial response to biological treatment have led to the use of off-label therapeutic intensification regimens, either by increasing the dose or by shortening the administration intervals.41,42 Therapeutic intensification, although it allows avoiding secondary inefficacy, entails additional costs and, moreover, the safety of increased exposure to immunosuppressive agents is not clearly studied.43 In addition, the use of multiple cycles of therapeutic intensification was associated with lower efficacy, with lower reductions of PASI in a second intensification cycle when compared with reduction of PASI obtained in the first cycle.28
Psoriasis Medical Images J Invest Dermatol. 1981; 76: 359-362 Fat and Fats - What do you know about fat? Scalp psoriasis
Psoriasis is thought to have first been described in Ancient Rome by Cornelius Celsus. The disease was first classified by English physician Thomas Willan. The British dermatologist Thomas Bateman described a possible link between psoriasis and arthritic symptoms in 1813.
Barton A Master Dermatologist Award Former boxing champion-turned-actor Victor Ortiz, 31, who...
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26. Svedbom A, Dalén J, Mamolo C, Cappelleri JC, Petersson IF, Ståhle M. Treatment patterns with topicals, traditional systemics and biologics in psoriasis - a Swedish database analysis. J Eur Acad Dermatol Venereol. 2015;29:215–223. [PubMed]
Gluten sensitivity and psoriasis: What's the connection? Insect Bite Reactions
Dr. Feldman has received honoraria from Westwood-Squibb Pharmaceuticals and Glaxo Wellcome, Inc.; has served as a consultant for Allergan, Inc., Glaxo Wellcome, Inc., Ortho Pharmaceutical Corp., and Westwood-Squibb Pharmaceuticals; has received grant or research support from Glaxo Wellcome, Inc., Ortho Pharmaceutical Corp., and Westwood-Squibb Pharmaceuticals, and has served on the speakers bureau for Allergan, Inc., and Westwood-Squibb Pharmaceuticals.
When stratifying participants according to the PASI and DLQI, patients with greater impairment of the quality of daily life (DLQI >10) attached greater importance to the probability of improvement compared with those with a lower DLQI, as expected. By contrast, the PASI was negatively correlated with participants' preference for the probability of improvement. This finding may reflect the low correlation between objective clinical severity and psychological disability in psoriasis.43 However, the PASI measured in this study does not reflect the severity of psoriasis in these participants because many had achieved significant control with use of systemic medications. Finally, patients who place great value on the probability of improvement are likely to adhere to prescribed treatments, resulting in favorable outcomes shown in a low PASI.
YouTube The chronic course of psoriasis and the increase in life expectancy mean that elderly patients represent a significant subset of patients with psoriasis.
Psoriasis vulgaris L40.0 Pigmentation disorders Comorbidities associated with psoriasis include other immune conditions such as psoriatic arthritis and Crohn’s disease.
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