Related Conditions Psoriasis is a common chronic inflammatory skin disorder affecting individuals with an underlying genetic predisposition. The disease manifests following exposure to various triggers (e.g., infection, medication). The typical lesions are sharply demarcated, erythematous, scaly, pruritic plaques, which occur most often on the extensor surfaces of the knees and elbows, but may also affect the scalp and back. Other common clinical findings include involvement of the nails (e.g., pitting or discoloration) or joints, which generally manifests with arthritis of the fingers and lower spine. As psoriasis presents with several subtypes, the size, location, and severity of the lesions vary. The diagnosis is based primarily on clinical findings, but may also be confirmed with tests (e.g., Auspitz sign) or biopsy. Mild psoriasis is treated with topical agents such as steroids, whereas moderate to severe disease requires systemic therapy (e.g., PUVA, biologics).
What medication has worked best for your psoriasis? Coal Tar Is One of the Oldest Psoriasis Remedies
Psoriasis is a common, chronic skin condition, driven by an overactive immune system. It is not caused by dirty skin and is definitely not contagious.
Pregnancy (Note: A pregnant woman should not use or take a retinoid medicine.) Orthopedic & Muscular System: Current Research Open Access Journal
Scopus (182) Other therapies There are eight main types of psoriasis - here's how you can identify them:
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Hide comments The American Academy of Dermatology (AAD) guidelines recommend treatment with methotrexate, cyclosporine, and acitretin, with consideration of contraindications and drug interactions. 
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Coping With IBS Möller S Regulatory T cells control VEGF-dependent skin inflammation. People's Experiences Australia Even though topical corticosteroids such as creams or ointments are applied to the surface of the skin, they can still cause side effects. Long-term use or excessive use can lead to thinning of the skin, irritation, dryness, or changes in skin color. If your doctor recommends that you occlude your psoriasis areas -- wrapping them in plastic after applying a topical corticosteroid to boost the effect -- side effects may be more common.
Insights in Biomedicine Open Access Journal Cancer-Related Gene Variations Frequently Reclassified ^ Jump up to: a b c d e f g h "Questions and Answers about Psoriasis". National Institute of Arthritis and Musculoskeletal and Skin Diseases. October 2013. Archived from the original on 8 July 2015. Retrieved 1 July 2015.
Plaque psoriasis — Medscape Of those affected by psoriasis, up to 80% will have involvement of the scalp.5 Scalp psoriasis may occur in isolation or in conjunction with other forms of psoriasis. Scalp psoriasis is characterized by red, thickened plaques with silver-white scale, either contained within the hairline, or extending onto the forehead, ears, and posterior neck.6 Importantly, scalp psoriasis can be a cause of great physical and social distress, with up to 97% of affected individuals reporting that the condition interferes in their daily life.7 In many cases, scalp psoriasis is associated with intense pruritus, and scale is commonly shed as dandruff creating significant social embarrassment for affected individuals. In a recent multinational survey, 43% of respondents to a telephone survey identified itch as the most bothersome symptom of their psoriasis.8 Moreover, scalp psoriasis can also result in alopecia. Although this is commonly reversible with appropriate treatment, increasing evidence links scarring alopecia with chronic, relapsing episodes of the disease.9
Messana JM HOME TOURS Strauss and Katz Scholarship problems Journal of Nutraceuticals and Food Science Open Access Journal Eat a heart-healthy diet
Norway More in Pubmed Profile Info Exp Dermatol. 2011; 20: 303-307 Search form Journal of Biodiversity & Endangered Species Open Access Journal Handheld Scanner Reveals Vascularization in Psoriasis Patients
The Lancet Psychiatry Tongue Problems Visit WebMD on Facebook Five people we talked to had taken cyclosporine (Zara, Lucy, Hannah, Lisa, Sofia) and five people had tried methotrexate (Zara, Lucy, Hannah, Lisa, Megan). Everyone had taken their medicines in tablet form and Hannah had also tried methotrexate injections. Some people had tried a medicine several times at different points in their psoriasis treatment: Lisa took cyclosporine for 1 year, then methotrexate for 6 months, went back to cyclosporine for 1 month, stopped medication when living abroad and back to methotrexate when she returned to the UK. Lucy’s taken cyclosporine and methotrexate in the past, but doesn’t like “pumping my body full of medicine”. She prefers phototherapy as a psoriasis treatment.
Climatotherapy In a population-based cross-sectional study of 9035 psoriasis patients and 90,350 matched controls without psoriasis, those with more extensive psoriatic skin disease were at greater risk for major medical comorbidities, including heart and blood vessel disease, chronic lung disease, diabetes, kidney disease, joint problems, and other health conditions. [17, 18] Overall, the risk for any other type of serious illness was 11% higher for people with mild psoriasis, 15% higher for patients with moderate psoriasis, and 35% higher for those with severe psoriasis. [17, 18]
Patient Comments: Scalp Psoriasis - Creams and Lotions Psoriasis is an autoimmune disorder where rapid skin cell reproduction results in raised, red and scaly patches of skin. It is not contagious. It most commonly affects the skin on the elbows, knees, and scalp, though it can appear anywhere on the body.
Oncology & Cancer Case Reports Open Access Journal You may wish to read the following sections on this to learn about the various aspects of psoriasis in more detail:
Rotational therapy refers to the substitution of one therapy for another after 1 to 2 yr to reduce the adverse effects caused by chronic use and to circumvent disease resistance. Sequential therapy refers to initial use of potent agents (eg, cyclosporine) to quickly gain control followed by use of agents with a better safety profile. Immunomodulatory agents achieve clearance or near clearance of lesions more often than methotrexate or NBUVB.
10 allergy myths: busted Keratolytic Agents Temporary hair loss due to constant scratching N Engl J Med. 1974; 291: 1207-1211 North Chicago, IL 60064 +
Patient Bill of Rights 27. Tar allergy Pustular psoriasis is a rarer type of psoriasis that causes pus-filled blisters (pustules) to appear on your skin. Different types of pustular psoriasis affect different parts of the body.
Ultraviolet B (UV-B) light therapy is usually combined with topical treatments and is effective for treating moderate-to-severe plaque psoriasis. There is a risk of skin cancer, just as there is from natural sunlight.
Narrowband UVB is particularly effective in thin chronic plaque psoriasis and guttate psoriasis, especially in the winter months.
Treatment: Potent systemic drugs (eg, methotrexate, cyclosporine, TNF-alpha inhibitor) or intense topical therapy, sometimes as inpatient therapy
Ustekinumab 90mg (s12) 76.8 (71.7-81.9) 66.5 (60.2-72.9) 35.5 (29.0-42.0)
Cochrane.org Cutaneous variants Day Surgery Denise Mann, MS Two drugs that target T cells are efalizumab and alefacept. Efalizumab is a monoclonal antibody that specifically targets the CD11a subunit of LFA-1. It also blocks the adhesion molecules on the endothelial cells that line blood vessels, which attract T cells. Efalizumab was voluntarily withdrawn from the European market in February 2009 and from the US market in June 2009 by the manufacturer due to the medication's association with cases of progressive multifocal leukoencephalopathy. Alefacept also blocks the molecules that dendritic cells use to communicate with T cells and even causes natural killer cells to kill T cells as a way of controlling inflammation. Apremilast may also be used.
Preventing Psoriasis Flare-Ups Simply fill out this form and we'll send them an email Nail psoriasis and arthritis may also be present
Indications: psoriasis, lichen planus, scleroderma, vitiligo, mycosis fungoides 2016 Genitalia
Media contacts Vitamin D derivatives (calcipotriene)
Obesity. People with psoriasis, especially those with more severe disease, are more likely to be obese. It's not clear how these diseases are linked, however. The inflammation linked to obesity may play a role in the development of psoriasis. Or it may be that people with psoriasis are more likely to gain weight, possibly because they're less active because of their psoriasis.
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Certain medicines (for high blood pressure or medications that treat a disease called malaria.)
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Regardless of the severity, scalp psoriasis can impact a person’s quality of life.
Jump up ^ Ship, Martin S. Greenberg, Michael Glick, Jonathan A. (2008). Burket's oral medicine (11th ed.). Hamilton, Ont.: BC Decker. pp. 103–4. ISBN 1-55009-345-2.
Successfully treating psoriasis Schlager J, Rosumeck S, Werner R, Jacobs A, Schmitt J, Schlager C, Nast A. Topical treatments for scalp psoriasis. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD009687. DOI: 10.1002/14651858.CD009687.pub2
Symptoms Mayo clinic The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies.
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Correlation with HLA Strong association with HLA (HLA-Cw6, HLA-B17 and HLA-B57) Rarely correlated with HLA
Arch Dermatol. 1991; 127: 1333-1338 The therapy is done in a doctor's office, psoriasis clinic, or at home with a phototherapy unit. The FDA regulates medical devices used in the application of phototherapy. Laser treatments, using a device known as an excimer laser, can administer highly targeted beams of ultraviolet light to treat select areas of affected skin.
Carers: terminal illness Psoriasis is an autoimmune disease, meaning that part of the body’s own immune system becomes overactive and attacks normal tissues in the body.
Patient Comments: Psoriasis - Diet Irina Shayk flashes a glimpse of her midriff in a slinky cardigan after working up a sweat in LA Showed off her nicely toned physique
Snellman E Cetaphil Signs and symptoms Browse by Product Area Climatotherapy, the oldest form of phototherapy involving exposure to sunlight, is well established at a number of clinics around the world. Perhaps the most successful is the psoriasis treatment centre at the Dead Sea.23 At 300 m below sea level, the Dead Sea is the lowest point on earth. Its mineral content is greater than that of any other naturally occurring body of water on earth. The extra 300 m through which sunlight has to pass, combined with the mineral haze over the Dead Sea, results in light exposure that has proved highly beneficial for psoriasis. Results are comparable with those obtained with broadband UVB phototherapy.24
Journal of Clinical & Experimental Cardiology Open Access Journal Additional types of psoriasis comprise approximately 10% of cases. They include pustular, inverse, napkin, guttate, oral, and seborrheic-like forms.
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Journal of Pulmonary & Respiratory Medicine Open Access Journal Mrowietz U There are also medications called biologics. Some you take as a shot, others you receive through a vein (IV). They suppress the immune system. Speak with your doctor about your options.
If you have the genetic basis of psoriasis, a trigger can cause psoriasis to flare up. The following are triggers that may set off one's psoriasis:
Jacquiline Habashy, DO, MSc is a member of the following medical societies: American Osteopathic College of Dermatology The growing knowledge on molecular and cellular bases involved in the pathogenesis of psoriasis has allowed the development of biological therapies directed to T lymphocytes and cytokines TNFα, IL-12, IL-23 and IL-17A.9-10
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Treatment of scalp psoriasis Sickle Cell Anemia Tazarotene (Tazorac) is a topical retinoid that is available as a gel or cream. This medicine is sometimes combined with corticosteroids to decrease skin irritation when used alone and to increase effectiveness. Tazarotene is particularly useful for psoriasis of the scalp.
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