NEW ARTICLESHomeTop Tregalizumab, another biotechnological agent under study in the treatment of psoriasis, which acts through the specific stimulation of a CD4 epitope, has the potential to exclusively activate regulatory T lymphocytes without activation of effector T lymphocytes, with an increase in anti-inflammatory cytokines (IL-10 and TGF-β), thus contributing to the disruption of the inflammatory cascade.15
PRINT THIS Psoriasis is characterized by an abnormally excessive and rapid growth of the epidermal layer of the skin. Abnormal production of skin cells (especially during wound repair) and an overabundance of skin cells result from the sequence of pathological events in psoriasis. Skin cells are replaced every 3–5 days in psoriasis rather than the usual 28–30 days. These changes are believed to stem from the premature maturation of keratinocytes induced by an inflammatory cascade in the dermis involving dendritic cells, macrophages, and T cells (three subtypes of white blood cells). These immune cells move from the dermis to the epidermis and secrete inflammatory chemical signals (cytokines) such as interleukin-36γ, tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-22. These secreted inflammatory signals are believed to stimulate keratinocytes to proliferate. One hypothesis is that psoriasis involves a defect in regulatory T cells, and in the regulatory cytokine interleukin-10.
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RECIPES Drug or food interactions: Topical salicylic acid inactivates calcipotriene. Do not use creams or ointments containing these medicines at the same time.
Midwest Region Picture of plaque psoriasis on the legs. Source: iStock.com. Available coming weekend
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Cargill M With full approval of our institutional review board, informed consent was obtained. The patient's scalp was mapped using clear plastic templates. Immediately before treatment, a score of 9 was noted on the modified Psoriasis Area and Severity Index (PASI), which is used to assess erythema, induration, and scaling (0, none; 1, slight; 2, moderate; 3, severe; and 4, very severe). Half of the large psoriatic plaque was treated with the 308-nm excimer laser using the scalp delivery device; the other half served as a control. Mineral oil was applied to both areas before the treatment began. A 2.5-cm spot size was used, with pulses delivered in a 25% overlapping fashion. The initial dose administered was 200 mJ/cm2, and subsequent doses were increased incrementally by 50 to 200 mJ/cm2 based on the patient's tolerance, ie, the sensation and/or clinical appearance of burning. Her final dose was 3600 mJ/cm2. The psoriatic plaque was to be treated 2 times per week, every 48 to 72 hours, for up to 30 treatments or until clinical clearing was noted (modified PASI score, ≤3). Our patient required only 22 treatments before clearing occurred. The average time of each painless treatment was less than 10 minutes. Between treatments and during the follow-up period, only the use of over-the-counter antidandruff shampoos was allowed.
Guigue P Moisturize and Cool to Stop the Itch Podiatry Service Clinical evaluation Recent changes
Anyone can have psoriasis. About 7.5 million people in the U.S. are affected, and it occurs equally in men and women. Psoriasis can occur at any age but is most often diagnosed between the ages of 15 to 25. It is more frequent in Caucasians.
ultraviolet light therapy. Psoriasis medication: How long can I take a biologic? (video) David T Robles, MD, PhD is a member of the following medical societies: American Academy of Dermatology
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Insufficiency in protein escorter ASTN2 causes receptors to accumulate on cell surfaces, disrupting communication between neurons, a new mouse study shows.
Longo DL, et al., eds. Eczema, psoriasis, cutaneous infections, acne, and other common skin disorders. In: Harrison's Principles of Internal Medicine. 19th ed. New York, N.Y.: The McGraw-Hill Education; 2015. http://accessmedicine.com. Accessed Dec. 8, 2016.
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Learning Curves: Historical Trends of FDA-Reported Adverse Events for Dermal Fillers Coping with psoriasis can be a challenge, especially if the disease covers large areas of your body or is in places readily seen by other people, such as your face or hands. The ongoing, persistent nature of the disease and the treatment challenges only add to the burden.
Sponsored Content Latest content Lifestyle measures which may assist in the treatment of psoriasis include: ST Wine Journal of Food & Industrial Microbiology Open Access Journal
I cannot afford my psoriasis medications! Now what?
Alzheimer's disease: carers of people with Trüeb RM Sweepstakes and Prizes If you’re feeling embarrassed or self-conscious about your scalp psoriasis, a hat, hair accessories, or a new haircut can help you conceal your lesions and flaking. When choosing a hat or accessories, however, be sure to avoid hats that are tight or can cause friction, as they may worsen your symptoms. If you’re getting a haircut, be sure to let your stylist know about your condition, so he can take extra care when selecting hair products and cutting, washing, and styling your hair.
it is important to persevere with treatments because they can control the disease Scientists Determine Four Personality Types Based on New Data Coal tar is a thick, heavy oil and is probably the oldest treatment for psoriasis. How it works is not exactly known, but it can reduce scales, inflammation and itchiness.
Day Surgery Partners Injury 8. Vincent FB, Morand EF, Murphy K, Mackay F, Mariette X, Marcelli C. Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralising agents in chronic inflammatory diseases: a real issue, a clinical perspective. Ann Rheum Dis. 2013;72:165–178. [PubMed]
Dandruff-like flaking and silvery-white scale. Scalp psoriasis can look a lot like dandruff. Many people who have scalp psoriasis see flaking. But there are differences between scalp psoriasis and dandruff. Unlike dandruff, scalp psoriasis causes a silvery sheen and dry scale on the scalp.