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Participants assessed the efficacy of the treatments similarly to the investigator: those who applied a steroid or the combination product responded better to treatment than participants who used vitamin D alone. Statistically, the combination product was more effective than the steroid alone, but clinically the benefit was questionable.
Zhu TH, et al. The patient's guide to psoriasis treatment. Part 4: Goeckerman therapy. Dermatology and Therapy. 2016;6:333. Topical retinoids. These are vitamin A derivatives that may decrease inflammation. The most common side effect is skin irritation. These medications may also increase sensitivity to sunlight, so while using the medication apply sunscreen before going outdoors.
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Vitamin D analogues are used to help control overactive skin cell production by binding to the vitamin D receptors on the skin cells. Topical vitamin D analogues such as calcipotriene (Dovonex, Sorilux) and calcitriol (Vectical) are effective at slowing the growth of the skin cells and can be used with emollients and topical corticosteroids applied to the skin. Calcipotriene with betamethasone (Taclonex, Enstilar) is a vitamin D analogue that is already combined with a corticosteroid.
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