Article last updated by Yvette Brazier on Thu 27 July 2017. TOPICAL THERAPY
Although it is a relatively common condition, the exact cause of psoriasis has not yet been determined. However, we do know that it's related to the body's immune system and has a genetic predisposition (one third of patients with psoriasis report relatives with the disease).
PUVA is an acronym. The P stands for psoralen, the U for ultra, the V for violet and the A for that portion of the solar spectrum between 290 and 320 nanometers in wavelength. PUVA was originally developed to treat psoriasis.
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Narrow-band UVB phototherapy is an artificial light treatment using very limited wavelengths of light. It is frequently given daily or two to three times per week. UVB is also a component of natural sunlight. UVB dosage is based on time and exposure is gradually increased as tolerated. Potential side effects with UVB include skin burning, premature aging, and possible increased risk of skin cancer. The relative increase in skin cancer risk with UVB treatment needs further study but is probably less than PUVA or traditional UVB.
Basketball Back Pain Treatment in Singapore About Drugs.com Oral medications include methotrexate (Trexall), acitretin (Soriatane), cyclosporine (Neoral), apremilast (Otezla), and others. Oral prednisone (corticosteroid) is generally not used in psoriasis and may cause a disease flare-up if administered.
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A proposal to minimize the toxicity of some of these medicines has been commonly called "rotational" therapy. The idea is to change the anti-psoriasis drugs every six to 24 months in order to minimize the toxicity of one medication. Depending on the medications selected, this proposal can be an option. An exception to this proposal is the use of the newer biologic medications as described below. An individual who has been using strong topical steroids over large areas of their body for prolonged periods may benefit from stopping the steroids for a while and rotating onto a different therapy.
Afifi T, de Gannes G, Huang C, Zhou Y. Topical Therapies for Psoriasis. Canadian Family Physician. April 10, 2005. Jenna Coleman turned down the role of Queen Victoria TWICE before accepting... and admits her days are numbered when it comes to playing the monarch
Aviva Romm, M.D. other parts of the face Scopus (67) Augmentation of oral methoxsalen-photochemotherapy with an oral retinoic acid derivative.
What Are Psoriasis Treatments? Reports in Thyroid Research 34. Zaghloul SS, Goodfield MJ. Objective assessment of compliance with psoriasis treatment. Arch Dermatol. 2004;140(4):408–414. [PubMed]
Light therapy (phototherapy) Parnham J J Eur Acad Dermatol Venereol. 2013; 27: 1440-1443
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Cell & Developmental Biology Open Access Journal Krueger G, Koo J, Lebwohl M, et al. The impact of psoriasis on quality of life: Results of a 1998 National Psoriasis Foundation patient-membership survey. Arch Dermatol. 2001; 137(3): 280-4. [Abstract | Full text]
Exum ML Psoriasis is a skin condition that causes red, flaky, crusty patches of skin covered with silvery scales. Current Research GastroIntestinal History of skin cancer
Psoriasis and major adverse cardiovascular events: a systematic review and meta-analysis of observational studies.
Advances in Robotics & Automation Open Access Journal 42. Tyring S, Mendoza N, Appell M, et al. A calcipotriene/betamethasone dipropionate two-compound scalp formulation in the treatment of scalp psoriasis in Hispanic/Latino and Black/African American patients: results of the randomized, 8-week, double-blind phase of a clinical trial. Int J Dermatol. 2010;49(11):1328–1333. [PubMed]
Shampoos, scale softeners, and other treatments Patient Navigation Center Resources Tuesday, December 8, 2015 Jump up ^ Stanway A. "Erythrodermic psoriasis". DermNet NZ. Archived from the original on 2 February 2014. Retrieved 16 March 2014.
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These factors should be avoided whenever possible by people with psoriasis. There are probably others that we haven't discovered yet. Norway
What You Can Do: Reach Out Reviewed on 11/20/2017 Brain and Nervous system Some things may cause a flare, meaning your psoriasis becomes worse for a while, including:
Skin cells, which are made deep in the skin, normally take about a month to rise to the surface, where they die and are sloughed off. When psoriasis triggers T cells to attack healthy skin, the immune system responds by sending more blood to the area and making more skin cells and more white blood cells. This forces skin cells to rise to the surface in a few days instead of a month. The dead skin and white blood cells can't be shed quickly enough, and they build up on the surface of the skin as thick, red patches. As the skin cells die, they form silvery scales that eventually flake off.
10 Psoriasis Triggers to Avoid Other forms of light therapy include the use of artificial ultraviolet A (UVA) or ultraviolet B (UVB) light, either alone or in combination with medications.
Full Text Avoid irritating cosmetics or soaps.
41. Luger TA, Cambazard F, Larsen FG, et al. A study of the safety and efficacy of calcipotriol and betamethasone dipropionate scalp formulation in the long-term management of scalp psoriasis. Dermatology. 2008;217(4):321–328. [PMC free article] [PubMed]
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